In order to study the evolution of WNV in the US since , the FDA scientists analyzed the genes of viruses isolated from samples of blood donated by 19 human donors who tested positive for the infection during the US outbreak. They also examined previously identified sequences of WNV genes from samples obtained from — A genetic sequence is the order of building blocks making up a specific gene.
Analyzing sequences enables scientists to identify mutations and study how an organism is evolving over time. The scientists detected several codons in the WNV genetic material that had undergone mutations that remained in a variety of virus populations over the years.
Codons are sections of genes that code for amino acids, the building blocks of proteins. Find a Funding Opportunity. Apply for a Grant. After You Submit an Application. Manage Your Award. Funding News. As a result, golden hamsters and mice are now used to test the efficacy of WNV vaccine candidates and antiviral treatments. NIAID-supported researchers are studying the different ways the immune system responds to WNV and how these responses interact to affect infection.
Scientists are also examining how WNV evolves and adapts to changing environments and the structural changes that occur to the virus when it replicates. Using genetic analysis, they compared different WNV strains to see if the virus has changed over time. In addition, the center has long provided research resources, such as viral isolates and reagents, to the scientific community.
In July , in a NIAID-supported observational study of WNV patients in the Houston area, researchers at the Baylor College of Medicine discovered chronic kidney disease among 40 percent of patients long after recovery from acute disease.
The study highlights the continuing need to investigate the pathology behind persistent infections, clinical outcomes, and treatment options. Skip to main content. Skip to Back. Search for Resources. Division of Intramural Research Labs. Research at Vaccine Research Center. Clinical Research. Infectious Diseases. Resources for Researchers. Managing Symptoms. Understanding Triggers. Autoimmune Diseases. Disease-Specific Research.
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Results: A total of publications were considered in this study, which were published between and The annual quantity of literature published before followed a low rate of research growth; while the quantity of publications after were published in a stage of rapid development. All publications related to WNV achieved h-index of and were cited , times.
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